Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats

Mesripour, Azadeh and Iyer, Abishek and Brown, Lindsay (2012) Mineralocorticoid receptors mediate cardiac remodelling in morphine-dependent rats. Basic and Clinical Pharmacology and Toxicology, 111 (2). pp. 75-80. ISSN 1742-7835


Acute morphine administration decreases cardiac responses to ischaemic injury. This project has determined whether
induction of morphine dependence in rats by gradually increasing morphine doses for 21 days induces structural and functional changes in the cardiovascular system because of mineralocorticoid receptor activation, as morphine increases plasma corticosterone concentrations. Morphine-dependent rats showed ventricular hypertrophy, increased collagen deposition in the left ventricle together with an increased ventricular stiffness and increased plasma malondialdehyde concentrations without changes in systolic
blood pressure or thoracic aortic responsiveness. These parameters were attenuated or normalised in morphine-dependent rats treated with spironolactone (50 mg/kg/day) from days 14–21. These results suggest that morphine dependence induces ventricular remodelling and increased oxidative stress that can be prevented by the mineralocorticoid receptor antagonist, spironolactone.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version due to publisher copyright policy (Wiley-Blackwell).
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 09 Sep 2012 06:15
Last Modified: 06 Nov 2014 03:21
Uncontrolled Keywords: opiates; heart attack; cardiac remodelling; blood pressure
Fields of Research : 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
10 Technology > 1004 Medical Biotechnology > 100499 Medical Biotechnology not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1111/j.1742-7843.2012.00860.x
URI: http://eprints.usq.edu.au/id/eprint/21873

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