Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling

Alam, Md. Ashraful and Uddin, Shaikh Jamal and Brown, Lindsay (2012) Mitogen-activated protein kinase and natural phenolic compounds in cardiovascular remodeling. In: Bioactive natural products. Studies in Natural Products Chemistry (38). Elsevier, Amsterdam, Netherlands, pp. 159-190. ISBN 978-0-444-59530-0


Cellular responses require the activation of intracellular signal transduction pathways, particularly the activation of protein kinases. Mitogen-activated protein kinases (MAPKs) are responsible for a diverse range of physiological processes in cells including growth, survival, and apoptosis. Three different kinases, known as extracellular signal-regulated kinases (ERKs), c-Jun N-terminal kinases (JNKs), and p38 MAPKs, are activated by dual phosphorylation on both threonine and tyrosine residues within a Thr-Xaa-Tyr motif. JNKs and p38 MAPKs trigger apoptosis whereas ERKs are responsible for cellular survival in the presence of noxious stimuli. Intracellular stress mediated via free radical generation and other proinflammatory mediators may activate the MAPKs. Impaired G-protein-coupled receptor signaling, responsible for most of the complications associated with obesity and cardiovascular disorders, activates the MAPK pathway, which ultimately activates downstream transcription factors and gene expression related to cardiac growth. Polyphenolic compounds possessing strong antioxidant and anti inflammatory properties improve stress-activated disorders such as hypertension, atherosclerosis, cardiac hypertrophy, and remodeling. This review focuses on the underlying mechanisms of cardiac remodeling in oxidative stress and the therapeutic potential of natural compounds inhibiting MAPKs.

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Item Type: Book Chapter (Commonwealth Reporting Category B)
Refereed: Yes
Item Status: Live Archive
Additional Information: Chapter 6. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means electronic, mechanical, photocopying, recording or otherwise without the prior written permission of the publisher.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 16 Sep 2012 05:45
Last Modified: 20 Apr 2017 04:33
Uncontrolled Keywords: mitogen-activated protein kinase; oxidative stress; GPCR; phenolic compounds
Fields of Research : 03 Chemical Sciences > 0304 Medicinal and Biomolecular Chemistry > 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060111 Signal Transduction
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/B978-0-444-59530-0.00006-X

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