Tumor-induced effects on PO2 distribution in a normal tissue

Li, Mao and Li, Yan ORCID: https://orcid.org/0000-0002-4694-4926 and Wen, Peng (Paul) ORCID: https://orcid.org/0000-0003-0939-9145 (2012) Tumor-induced effects on PO2 distribution in a normal tissue. In: 2012 IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics (BHI 2012), 2-7 Jan 2012, Hong Kong and Shenzhen, China.


A tumor in a normal tissue will introduce some significant physiological and pathological changes to the adjacent normal tissues. To quantitatively study how the tumor affects the partial oxygen pressure (PO2) distribution in a
normal tissue, an improved Krogh’s cylinder model that is more realistic than an assumption of homogeneous PO2 distribution in a certain region is used to describe the oxygen diffusion from a capillary into its surrounding tissue. In this study, a comparison of the oxygen transport in a normal tissue without tumors and with an implanted tumor is presented. The results show that when a tumor is implanted at the upstream part of a capillary, the entire surrounding normal tissue that is located at the downstream part of the capillary suffers from a low level of oxygen, and the PO2 in the normal tissue decreases by an average of 16%. In contrast, a tumor located at the downstream part of a capillary makes a slight impact on the PO2 distribution
in the upstream normal tissue. However, in both situations, a part of the tumor mass that is far from the capillary is in the quiescent even necrotic status due to the lack of sufficient supply of oxygen.

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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Paper)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2012 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Maths and Computing (Up to 30 Jun 2013)
Faculty/School / Institute/Centre: Historic - Faculty of Sciences - Department of Maths and Computing (Up to 30 Jun 2013)
Date Deposited: 25 Oct 2012 02:17
Last Modified: 15 Sep 2017 04:14
Uncontrolled Keywords: tumor growth; oxygen transport; diffusion; cylinder model
Fields of Research (2008): 10 Technology > 1004 Medical Biotechnology > 100402 Medical Biotechnology Diagnostics (incl. Biosensors)
01 Mathematical Sciences > 0102 Applied Mathematics > 010202 Biological Mathematics
08 Information and Computing Sciences > 0801 Artificial Intelligence and Image Processing > 080110 Simulation and Modelling
Fields of Research (2020): 32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320602 Medical biotechnology diagnostics (incl. biosensors)
49 MATHEMATICAL SCIENCES > 4901 Applied mathematics > 490102 Biological mathematics
46 INFORMATION AND COMPUTING SCIENCES > 4602 Artificial intelligence > 460207 Modelling and simulation
Socio-Economic Objectives (2008): E Expanding Knowledge > 97 Expanding Knowledge > 970108 Expanding Knowledge in the Information and Computing Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: https://doi.org/10.1109/BHI.2012.6211594
URI: http://eprints.usq.edu.au/id/eprint/21221

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