In vitro biodegradation behavior of magnesium and magnesium alloy

Wang, Hao and Shi, Zhiming (2011) In vitro biodegradation behavior of magnesium and magnesium alloy. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 98B (2). pp. 203-209. ISSN 1552-4973

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Magnesium has the potential to be used as degradable
metallic biomaterial. For magnesium and its alloys to be
used as biodegradable implant materials, their degradation
rates should be consistent with the rate of healing of the
affected tissue, and the release of the degradation products
should be within the body's acceptable absorption levels.
Conventional magnesium degrades rapidly, which is undesirable.
In this study, biodegradation behaviors of high purity
magnesium and commercial purity magnesium alloy AZ31 in
both static and dynamic Hank's solution are systematically
investigated. The in vitro test results show that magnesium
purification and selective alloying are effective approaches to reduce the degradation rate of magnesium. In the static condition, the corrosion products accumulate on the materials surface as a protective layer, which results in a lower degradation rate than the dynamic condition. Anodized coating can significantly further reduce the degradation rate of magnesium. This study strongly indicates that magnesium can be used as degradable implant material as long as the degradation is controlled at a low rate. Magnesium purification, selective alloying, and anodized coating are three effective approaches to reduce the rate of degradation.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2011 Wiley Periodicals, Inc. Permanent restricted access to published version due to publisher copyright policy.
Faculty / Department / School: Historic - Faculty of Engineering and Surveying - Department of Mechanical and Mechatronic Engineering
Date Deposited: 05 May 2012 02:02
Last Modified: 27 Aug 2014 00:56
Uncontrolled Keywords: magnesium; magnesium alloy; biodegradation; biodegradable materials; biodegradable implant; biocorrosion
Fields of Research : 09 Engineering > 0903 Biomedical Engineering > 090304 Medical Devices
03 Chemical Sciences > 0303 Macromolecular and Materials Chemistry > 030304 Physical Chemistry of Materials
09 Engineering > 0912 Materials Engineering > 091207 Metals and Alloy Materials
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970109 Expanding Knowledge in Engineering
Identification Number or DOI: 10.1002/jbm.b.31769

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