Wong, Weng-Yew and Brown, Lindsay (2011) Nutrapharmacology of tocotrienols for metabolic syndrome. Current Pharmaceutical Design, 17 (21). pp. 2206-2214. ISSN 1381-6128
Abstract
Metabolic syndrome is defined as a set of health risk factors that are associated with an increased chance of cardiovascular diseases and type 2 diabetes. These include abdominal obesity, hyperglycemia, impaired glucose tolerance, dyslipidemia, and hypertension. Interventions in metabolic syndrome include lifestyle interventions such as a healthy diet using functional foods together with increased physical activity to induce weight loss as the first aim of treatment. Nutraceuticals such as tocotrienols and tocopherols as members of the vitamin E family may be more targeted interventions. This review evaluates the effects of tocotrienols on the risk factors of metabolic syndrome using data from human, animal and in vitro studies. Tocotrienols improved lipid profiles and reduced atherosclerotic lesions, decreased blood glucose and glycated hemoglobin concentrations, normalized blood pressure, and inhibited adipogenesis. The differences in responses between tocopherols and tocotrienols in preventing obesity, diabetes, hypertension, atherosclerosis, ischemia, and inflammation suggest that different receptors or signaling mechanisms may be involved.
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| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Refereed: | Yes |
| Item Status: | Live Archive |
| Additional Information: | © 2011 Bentham Science Publishers. Permanent restricted access to published version due to publisher copyright policy. |
| Faculty / Department / School: | Historic - Faculty of Sciences - Department of Biological and Physical Sciences |
| Date Deposited: | 08 Feb 2012 06:18 |
| Last Modified: | 13 Feb 2015 02:21 |
| Uncontrolled Keywords: | metabolic syndrome; tocotrienols; tocopherols; diabetes; hypertension; atherosclerosis; adipogenesis; hepatocytes artherosclarosis; chylomicrons |
| Fields of Research : | 06 Biological Sciences > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified |
| Socio-Economic Objective: | C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes |
| Identification Number or DOI: | 10.2174/138161211796957445 |
| URI: | http://eprints.usq.edu.au/id/eprint/20728 |
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