Cardiac extracellular matrix: a dynamic entity

Brown, Lindsay (2005) Cardiac extracellular matrix: a dynamic entity. American Journal of Physiology: Heart and Circulatory Physiology, 289 (3 58-3). H973-H974. ISSN 0363-6135


Understanding the regulation of the extracellular matrix of
the heart is essential to understanding the chronic changes in
heart function in disease states such as hypertension, heart
failure, and diabetes. This understanding relies on overturning the concept that the extracellular matrix of the heart is inert.
Bouzeghrane and colleagues, by showing the presence of fibrillin in rodent hearts and its upregulation in
models of cardiac fibrosis, have demonstrated the dynamic
complexity of the extracellular matrix. Furthermore, they have added a potential target molecule for the understanding and modification of cardiac function in both the normal and diseased heart.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to paper due to publisher copyright restrictions.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 30 Oct 2011 04:34
Last Modified: 03 Jul 2013 00:50
Uncontrolled Keywords: heart disease; fibrillin; cardiac function
Fields of Research : 06 Biological Sciences > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified
06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1152/ajpheart.00443.2005

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