Resistance to ocular antibiotics: an overview

Brown, Lindsay (2007) Resistance to ocular antibiotics: an overview. Clinical and Experimental Optometry, 90 (4). pp. 258-262. ISSN 0816-4622

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The introduction of new antibiotic compounds into therapy initiates the development of resistance by the target bacteria. Resistance increases the risk of treatment failure with potentially serious consequences. Local application of antibacterial compounds to the eyes may lead to bacterial resistance in bacterial isolates from the eyes. The incidence of resistant strains of common pathogens is probably increasing. As compounds can be absorbed into the systemic circulation following ocular administration, the subsequent low concentrations in the blood could provide the selective pressure for the survival of resistant bacteria in the body. Despite this possibility, there are no reports of systemic resistance in bacteria following ocular administration of antibacterial compounds. All health-care professionals should be concerned about this possibility and continue to use these important compounds with respect.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published verison due to publisher copyright policy.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 07 Jul 2011 07:04
Last Modified: 03 Jul 2013 00:43
Uncontrolled Keywords: anti-bacterial agents; bacterial physiology; drug resistance; eye infections, bacterial; humans
Fields of Research : 11 Medical and Health Sciences > 1113 Ophthalmology and Optometry > 111301 Ophthalmology
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences
11 Medical and Health Sciences > 1108 Medical Microbiology > 110801 Medical Bacteriology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1111/j.1444-0938.2007.00154.x

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