Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee

Scott, A. and Lian, O. and Roberts, C. R. and Cook, J. L. and Handley, C. J. and Bahr, R. and Samiric, T. and Ilic, M. Z. and Parkinson, J. and Hart, D. A. and Duronio, V. and Khan, K. M. (2008) Increased versican content is associated with tendinosis pathology in the patellar tendon of athletes with jumper's knee. Scandinavian Journal of Medicine and Science in Sports, 18 (4). pp. 427-435. ISSN 0905-7188


Expansion of the extracellular matrix is a prominent but poorly characterized feature of tendinosis. The present study aimed to characterize the extent and distribution of the large aggregating proteoglycan versican in patients with patellar tendinosis. We obtained tendon from tendinopathy patients undergoing debridement of the patellar tendon and from controls undergoing intramedullary tibial nailing. Versican content was investigated by Western blotting and immunohistochemistry. Microvessel thickness and density were determined using computer-assisted image analysis. Markers for smooth muscle actin, endothelial cells (CD31) and proliferating cells (Ki67) were examined immunohistochemically. Western blot analysis and immunohistochemical staining revealed elevated versican content in the proximal patellar tendon of tendinosis patients (P=0.042). Versican content was enriched in regions of fibrocartilage metaplasia and fibroblast proliferation, as well as in the perivascular matrix of proliferating microvessels and within the media and intima of arterioles. Microvessel density was higher in tendinosis tissue compared with control tissue. Versican deposition is a prominent feature of patellar tendinosis. Because this molecule is not only a component of normal fibrocartilagenous matrices but also implicated in a variety of soft tissue pathologies, future studies should further detail both pathological and adaptive roles of versican in tendons.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restrcited access to published version due to publisher copyright policy. Article first published online: 7 Dec 2007.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 07 Nov 2011 05:51
Last Modified: 29 Aug 2014 03:34
Uncontrolled Keywords: versican; patellar tendon; tendinosis; extracellular matrix
Fields of Research : 11 Medical and Health Sciences > 1107 Immunology > 110705 Humoural Immunology and Immunochemistry
11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110601 Biomechanics
11 Medical and Health Sciences > 1116 Medical Physiology > 111699 Medical Physiology not elsewhere classified
Socio-Economic Objective: C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis)
Identification Number or DOI: 10.1111/j.1600-0838.2007.00735.x

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