Involvement of proteoglycans in tendinopathy

Parkinson, J. and Samiric, T. and Ilic, M. Z. and Cook, J. and Handley, C. J. (2011) Involvement of proteoglycans in tendinopathy. The Journal of Musculoskeletal and Neuronal Interactions, 11 (2). pp. 86-93. ISSN 1108-7161

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A major feature of chronic tendinopathy is a change in the nature and organisation of the extracellular matrix of tendon. Increased levels of proteoglycans have been shown in the extracellular matrix of tendinopathic tendons and these appear to influence the increased hydration and swelling of the tissue that is a feature of this condition. There is a paucity of knowledge about proteoglycans in normal and tendinopathic tendons. This review sets out to describe the nature, function and metabolism of proteoglycans present in normal tendon and in tendinopathy and outlines how changes in proteoglycan metabolism may contribute to the development and progression of this disease.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Copyright: Authors submitting manuscripts to JMNI retain the copyright of the article if it is published.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 24 Jul 2011 05:37
Last Modified: 25 Aug 2014 01:55
Uncontrolled Keywords: proteoglycans, tendinopathy, tendon
Fields of Research : 11 Medical and Health Sciences > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
06 Biological Sciences > 0601 Biochemistry and Cell Biology > 060104 Cell Metabolism
11 Medical and Health Sciences > 1103 Clinical Sciences > 110322 Rheumatology and Arthritis
Socio-Economic Objective: C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis)

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