Panchal, Sunil K. and Brown, Lindsay (2011) Rodent models for metabolic syndrome research. Journal of Biomedicine and Biotechnology. pp. 1-14. ISSN 1110-7243
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Abstract
Rodents are widely used to mimic human diseases to improve understanding of the causes and progression of disease symptoms and to test potential therapeutic interventions. Chronic diseases such as obesity, diabetes and hypertension, together known as the metabolic syndrome, are causing increasing morbidity and mortality. To control these diseases, research in rodent models that closely mimic the changes in humans is essential. This review will examine the adequacy of the many rodent models of metabolic
syndrome to mimic the causes and progression of the disease in humans. The primary criterion will be whether a rodent model initiates all of the signs, especially obesity, diabetes, hypertension and dysfunction of the heart, blood vessels, liver and kidney, primarily by diet since these are the diet-induced signs in humans with metabolic syndrome. We conclude that the model that
comes closest to fulfilling this criterion is the high carbohydrate, high fat-fed male rodent.
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Item Type: | Article (Commonwealth Reporting Category C) |
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Refereed: | Yes |
Item Status: | Live Archive |
Additional Information: | Copyright © 2011 S. K. Panchal anThis is an open access article distributed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.d L. Brown. |
Faculty/School / Institute/Centre: | Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013) |
Faculty/School / Institute/Centre: | Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013) |
Date Deposited: | 10 Jun 2011 03:55 |
Last Modified: | 01 Mar 2016 23:45 |
Uncontrolled Keywords: | metabolic syndrome; rodents; carbohydrate diet; causal attribution; chemically induced disorder; diabetes mellitus |
Fields of Research (2008): | 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine 11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology |
Fields of Research (2020): | 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320507 Metabolic medicine 32 BIOMEDICAL AND CLINICAL SCIENCES > 3210 Nutrition and dietetics > 321004 Nutritional science 32 BIOMEDICAL AND CLINICAL SCIENCES > 3214 Pharmacology and pharmaceutical sciences > 321401 Basic pharmacology |
Socio-Economic Objectives (2008): | E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences |
Identification Number or DOI: | https://doi.org/10.1155/2011/351982 |
URI: | http://eprints.usq.edu.au/id/eprint/19007 |
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