A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats

Patel, Jatin and Matnor, Nur Azim and Iyer, Abishek and Brown, Lindsay (2011) A regenerative antioxidant protocol of vitamin E and alpha-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats. Evidence-Based Complementary and Alternative Medicine. pp. 1-8. ISSN 1741-427X

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Type 2 diabetes is a major cause of cardiovascular disease. We have determined whether the metabolic and cardiovascular changes induced by a diet high in fructose in young adult male Wistar rats could be prevented or reversed by chronic intervention with natural antioxidants. We administered a regenerative antioxidant protocol using two natural compounds: α-lipoic acid together with vitamin E (α-tocopherol alone or a tocotrienol-rich fraction), given as either a prevention or reversal protocol in the food. These rats developed glucose intolerance, hypertension, and increased collagen deposition in the heart together with an increased ventricular stiffness. Treatment with a fixed combination of vitamin E (either α-tocopherol or tocotrienol-rich fraction, 0.84 g/kg food) and α-lipoic acid (1.6 g/kg food) normalized glucose tolerance, blood pressure, cardiac collagen deposition, and ventricular stiffness in both prevention and reversal protocols in these fructose-fed rats. These results suggest that adequate antioxidant therapy
can both prevent and reverse the metabolic and cardiovascular damage in type 2 diabetes.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Copyright © 2011 Jatin Patel et al. This is an open access article distributed under the Creative Commons Attribution 4.0 License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 29 Jun 2011 11:49
Last Modified: 01 Mar 2016 23:45
Uncontrolled Keywords: regenerative antioxidants; diabetes; type 2; fructose; heart disease
Fields of Research : 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: doi: 10.1155/2011/120801
URI: http://eprints.usq.edu.au/id/eprint/19006

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