Robust internal model control for depth of anaesthesia

Abdulla, Shahab Anna and Wen, Peng (2011) Robust internal model control for depth of anaesthesia. International Journal of Mechatronics and Automation, 1 (1). pp. 1-8. ISSN 2045-1059

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This paper investigates the depth of anaesthesia control problem during a surgery, where paralytic, analgesic and hypnotic are regulated by means of monitored administration of specific drugs. A robust internal model controller (RIMC) based on the Bispectral Index (BIS) is
proposed. The controller compares the measured BIS with its input reference to provide the expected propofol concentration, and then the controller manipulates the anaesthetic propofol concentration entering the anaesthetic system to achieve the desired BIS value. This study develops patient dose-response models and provides an adequate drug administration regimen to avoid under or over dosing of patients. Numerical simulations illustrate that the RIMC performed better than the traditional PID controller. The robust performance of the two controllers is
evaluated for a wide range of patient models by varying in patient parameters. The other relative performance is also compared for different BIS step settings.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version due to publisher's copyright restrictions.
Faculty/School / Institute/Centre: Historic - Faculty of Engineering and Surveying - Department of Electrical, Electronic and Computer Engineering
Date Deposited: 24 Mar 2011 03:13
Last Modified: 26 Sep 2017 04:28
Uncontrolled Keywords: internal model control; IMC; depth of anaesthesia; DoA
Fields of Research : 10 Technology > 1004 Medical Biotechnology > 100402 Medical Biotechnology Diagnostics (incl. Biosensors)
09 Engineering > 0903 Biomedical Engineering > 090303 Biomedical Instrumentation
11 Medical and Health Sciences > 1103 Clinical Sciences > 110301 Anaesthesiology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970110 Expanding Knowledge in Technology
Identification Number or DOI: 10.1504/IJMA.2011.039150

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