Lipid mediators and inflammation in glucose intolerance and insulin resistance

Iyer, Abishek and Brown, Lindsay (2010) Lipid mediators and inflammation in glucose intolerance and insulin resistance. Drug Discovery Today: Disease Mechanisms, 7 (3-4). e191-e197.


Clinical and epidemiological studies suggest that patients who are overweight or obese are at greater risk to develop glucose intolerance and insulin resistance leading to type II diabetes and cardiovascular disease. Despite many hypotheses, it has been difficult to pin-point the precise causes of insulin resistance or impaired glucose tolerance. This commentary aims to stimulate debate by providing some mechanistic insights into a unifying hypothesis by which disturbed lipid metabolism, increased circulating lipid-derived mediators and excess accumulation of toxic lipid metabolites in adipose, muscle, liver and pancreatic beta cells contribute to inflammation, insulin resistance and beta cell dysfunction in type II diabetes. This understanding will direct future drug discovery research to identify and develop novel compounds that can regulate both metabolic and immune/inflammatory systems to provide a dual strategy to combat metabolic disease, especially insulin resistance and type II diabetes.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2010 Elsevier Ltd. Permanent restricted access to published version in accordance with the copyright policy of the publisher.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 22 Mar 2011 12:59
Last Modified: 14 Oct 2014 00:49
Uncontrolled Keywords: metabolic disease; lipids; lipid metabolism; adipose tissue; adipose tissue cell; asthma; body mass; cardiovascular disease; cell stress
Fields of Research : 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111102 Dietetics and Nutrigenomics
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1016/j.ddmec.2010.12.001

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