Echinacea induced hsp70 alterations in leukocytes

Agnew, L. and Matthias, A. and Shipp, C. and Kauter, K. and Bone, K. and Watson, K. and Lehmann, R. (2010) Echinacea induced hsp70 alterations in leukocytes. In: 7th Tannin Conference/58th International Congress and Annual Meeting of the Society for Medicinal Plant Product Research, 29 Aug-2 Sep 2010, Berlin, Germany.

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Heat shock proteins (hsp) are expressed constitutively as well as induced in response to mild stress. These stress factors include inflammation, viral and bacterial infection, oxidative stress and cytotoxins. Altered hsp expression has been found in a number of disease states. Echinacea is used as a prophylactic to boost the immune system and has been previously shown to enhance hsp70 expression in leucocytes after mild heat shock. In this study, the effects of echinacea supplementation on hsp70 expression in the different leucocyte subpopulations has been examined. Twenty four healthy volunteers aged between 20 and 66 years with a body mass index ranging from 20.2 to 30.7 participated in the study. They consumed 2 echinacea tablets (4.42mg total alkylamides per tablet) twice a day for 14 days. Blood samples were taken on days 1 and 15 and hsp70 expression was determined by flow cytometry in whole blood with and without in vitro heat shock. Significant differences were observed in the percentage of several white cell subsets that expressed hsp70. CD4 and CD8 lymphocytes expressed significantly more hsp70 in both males and females after supplementation but in natural killer cells and B lymphocytes, expression of hsp70 were only significantly increased in the male participant cohort. These results indicate that Echinacea may play a role in activating the immune system when the body encounters a challenge such as a virus.

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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: No
Item Status: Live Archive
Additional Information: Copyright. This journal, including all individual contributions and illustrations published therein, is legally protected by copyright for the duration of the copyright period. This applies in particular to photocopy reproduction, copyright, cyclostyling, mimeographing or duplication of any kind, translating, preparation of microfilms, and electronic data processing and storage.
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 10 May 2011 06:41
Last Modified: 28 Aug 2013 02:02
Uncontrolled Keywords: echinacea; leukocytes; medical stress; inflammation; viral infections; bacterial infections; cytotoxins
Fields of Research : 11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified
11 Medical and Health Sciences > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
11 Medical and Health Sciences > 1103 Clinical Sciences > 110306 Endocrinology
Socio-Economic Objective: E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: 10.1055/s-0030-1264927

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