Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.

Michael, Adam P. and Grace, Emily J. and Kotiw, Michael and Barrow, Russell A. (2003) Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp. Australian Journal of Chemistry, 56 (1). pp. 13-15. ISSN 0004-9425

Abstract

Isochromophilone IX, a novel antibiotic active component was isolated from a penicillium species and investigated. Isochromophilone IX displays a specific rotation with the same sign as isochromophilone VI. It was found that isochromophilone represents the first occurrence of an γ-amino butyric acid (GABA) containing metabolite among only four naturally occuring members of this structure class.

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Item Type:	Article (Commonwealth Reporting Category C)
Refereed:	Yes
Item Status:	Live Archive
Additional Information:	Permanent restricted access to paper due to publisher copyright restrictions. (CSIRO)
Faculty/School / Institute/Centre:	Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013)
Faculty/School / Institute/Centre:	Historic - Faculty of Sciences - Department of Biological and Physical Sciences (Up to 30 Jun 2013)
Date Deposited:	30 Nov 2007 11:47
Last Modified:	03 Jul 2013 00:20
Uncontrolled Keywords:	amino acids; fungi; high performance liquid chromatography; isomers; mass spectrometry; metabolites
Fields of Research (2008):	06 Biological Sciences > 0605 Microbiology > 060501 Bacteriology 03 Chemical Sciences > 0399 Other Chemical Sciences > 039999 Chemical Sciences not elsewhere classified 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110101 Medical Biochemistry: Amino Acids and Metabolites 10 Technology > 1004 Medical Biotechnology > 100403 Medical Molecular Engineering of Nucleic Acids and Proteins
Fields of Research (2020):	31 BIOLOGICAL SCIENCES > 3107 Microbiology > 310701 Bacteriology 34 CHEMICAL SCIENCES > 3499 Other chemical sciences > 349999 Other chemical sciences not elsewhere classified 32 BIOMEDICAL AND CLINICAL SCIENCES > 3205 Medical biochemistry and metabolomics > 320501 Medical biochemistry - amino acids and metabolites 32 BIOMEDICAL AND CLINICAL SCIENCES > 3206 Medical biotechnology > 320603 Medical molecular engineering of nucleic acids and proteins
Socio-Economic Objectives (2008):	E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI:	https://doi.org/10.1071/CH02021
URI:	http://eprints.usq.edu.au/id/eprint/14391

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