In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin

Kotiw, Michael and Morgan, Michael and Lopez, Jesus and Taylor, Steven and Shiels, Ian (2007) In vitro and in vivo determination of ant-TNFa activity in canine plasma from donors subject to pre conditioning with endotoxin. In: SEPSIS 2007: International Sepsis Forum ISF , 26-29 Sep 2007, Paris, France.

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Abstract

Septic shock is characterized by cardiovascular and vasomotor failure that is induced by an uncontrolled cascade of inflammatory mediators such as TNFα, IL-1β and IL-6. In dogs, systemic bacterial infections, haemorrhage, trauma, gastric dilatation/volvulus and pancreatitis are the major causes of septic shock. While endotoxin is a recognized effector molecule that can initiate an inflammatory cascade, it has been reported that preconditioning with endotoxin can downregulate inflammatory cytokine responses to subsequent endotoxin challenge. This study reports the effect of endotoxin preconditioning on anti-TNFα activity present in plasma from canine donors.

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Item Type:	Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed:	Yes
Item Status:	Live Archive
Additional Information:	Poster 23
Faculty/School / Institute/Centre:	Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited:	30 Nov 2007 11:55
Last Modified:	23 May 2018 03:08
Uncontrolled Keywords:	bacterial infections; endotoxin; plasma; blood donations; canines; dogs; inflamation; septic shock
Fields of Research :	07 Agricultural and Veterinary Sciences > 0707 Veterinary Sciences > 070707 Veterinary Microbiology (excl. Virology) 06 Biological Sciences > 0608 Zoology > 060804 Animal Immunology 06 Biological Sciences > 0606 Physiology > 060602 Animal Physiology - Cell
Socio-Economic Objective:	E Expanding Knowledge > 97 Expanding Knowledge > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Identification Number or DOI:	10.1186/cc6002
URI:	http://eprints.usq.edu.au/id/eprint/12208

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