Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma

Subramanya, Manjunath S. and Hossain, Md. Belal and Khan, Shahjahan and Memon, Breda and Memon, Muhammed A. (2010) Meta-analysis of D1 versus D2 gastrectomy for gastric adenocarcinoma. In: 10th Islamic Countries Conference on Statistical Sciences (ICCSS-10): Statistics for Development and Good Governance, 20-23 Dec 2009, Cairo, Egypt.

Abstract

Objectives: To conduct a meta-analysis of randomized controlled trials evaluating the relative merits of limited (D1) versus extended lymphadenectomy (D2) for proven gastric adenocarcinoma. Data Sources and Review Methods: A search of Cochrane, Medline, PubMed, Embase, Science Citation Index and Current Contents electronic databases identified randomized controlled trials published in the English language between 1980 and 2008 comparing the outcomes D1 vs D2 gastrectomy for gastric adenocarcinoma. The meta-analysis was prepared in accordance with the Quality of Reporting of Meta-analyses (QUOROM) statement. The six outcome variables analysed included length of hospital stay; overall complication rate; anastomotic leak rate; re- operation rate; 30 day mortality rate and 5 year survival rate. Random effects meta-analyses were performed using odds ratios and weighted mean differences. Results: Six trials totalling 1876 patients (D1=946, D2=930) were analyzed. In five out of the six outcomes the summary point estimates favoured D1 over D2 group with a statistically significant reduction of (i) 7.12 days reduction in hospital stay (WMD -7.12, CI -12.90, -1.35, p=0.0001); (ii) 58% reduction in relative odds of developing postoperative complications (OR 0.42, CI 0.24, 0.71, p=0.0014); (iii) 59% reduction in anastomotic breakdown (OR 0.41, CI 0.26, 0.65, p=0.0002); 67% reduction in re-operation rate (OR 0.33, CI 0.15, 0.72, p=0.006) and 42% reduction in 30 day mortality rate (OR 0.58, CI 0.4, 0.85, p=0.0052). Lastly there was no significant difference in the 5 year survival (OR 0.97, CI 0.78, 1.20, p=0.76) between D1 and D2 gastrectomy patients. Conclusions: Based on this meta-analysis, D1 gastrectomy is associated with significant fewer anastomotic leaks, postoperative complication rate, reoperation rate, decreased length of hospital stay and 30 day mortality rate. Lastly the five year survival in D1 gastrectomy patients was similar to the D2 cohort.


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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Paper)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held. Fulltext citation: Subramanya, M S; Hossain, M B; Khan, S; Memon, B; and Memon, M A (2010). META-ANALYSIS OF D1 VERSUS D2 GASTRECTOMY FOR GASTRIC ADENOCARCINOMA. Proceedings of the Tenth Islamic Countries Conference on Statistical Sciences (ICCS-X), Volume I, 140–147.
Depositing User: Professor Shahjahan Khan
Faculty / Department / School: Historic - Faculty of Sciences - Department of Maths and Computing
Date Deposited: 27 Jan 2011 07:36
Last Modified: 04 Sep 2014 05:31
Uncontrolled Keywords: D1 gastrectomy; D2 gastrectomy; gastric cancer; lymphadenectomy; metaanalysis; randomized controlled trials; patient's outcome; postoperative complications
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1103 Clinical Sciences > 110307 Gastroenterology and Hepatology
Socio-Economic Objective (SEO2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures
URI: http://eprints.usq.edu.au/id/eprint/9326

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