Yin, Sheng and Boyle, Glen M. and Carroll, Anthony R. and Kotiw, Michael and Dearnaley, John and Quinn, Ronald J. and Davis, Rohan A. (2010) Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis. Journal of Natural Products, 73 (9). pp. 1586-1589. ISSN 0163-3864
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Official URL: http://pubs.acs.org/doi/abs/10.1021/np100329w
Identification Number or DOI: doi: 10.1021/np100329w
Abstract
Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.
| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Additional Information: | Permanent restricted access to paper due to publisher copyright restrictions. |
| Uncontrolled Keywords: | aplidium caelestis; quinolinecarboxylic acid; antibacterial activity; drug synthesis; high performance liquid chromatography; microorganism |
| Fields of Research (FOR2008): | 11 Medical and Health Sciences > 1108 Medical Microbiology > 110801 Medical Bacteriology 03 Chemical Sciences > 0305 Organic Chemistry > 030502 Natural Products Chemistry 11 Medical and Health Sciences > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified |
| Subjects: | UNSPECIFIED |
| Socio-Economic Objective (SEO2008): | E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences |
| ID Code: | 8823 |
| Deposited By: | |
| Deposited On: | 17 Oct 2010 19:21 |
| Last Modified: | 08 Feb 2012 14:33 |
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