Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis

Yin, Sheng and Boyle, Glen M. and Carroll, Anthony R. and Kotiw, Michael and Dearnaley, John and Quinn, Ronald J. and Davis, Rohan A. (2010) Caelestines A-D, brominated quinolinecarboxylic acids from the Australian ascidian Aplidium caelestis. Journal of Natural Products, 73 (9). pp. 1586-1589. ISSN 0163-3864

Abstract

Four new brominated natural products, caelestines A-D (1-4), have been isolated from the Australian ascidian Aplidium caelestis. The structures of 1-4 were determined by analysis of their NMR and MS data. This is the first report of brominated quinolinecarboxylic acids from nature. Compound 1 has been previously synthesized but not spectroscopically characterized. Compounds 1-4 were tested against three mammalian cell lines (MCF-7, NFF, and MM96L) and a panel of microbial strains and showed only minor cytotoxicity.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to paper due to publisher copyright restrictions.
Depositing User: Dr John Dearnaley
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 17 Oct 2010 09:21
Last Modified: 03 Jul 2013 00:03
Uncontrolled Keywords: aplidium caelestis; quinolinecarboxylic acid; antibacterial activity; drug synthesis; high performance liquid chromatography; microorganism
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1108 Medical Microbiology > 110801 Medical Bacteriology
03 Chemical Sciences > 0305 Organic Chemistry > 030502 Natural Products Chemistry
11 Medical and Health Sciences > 1108 Medical Microbiology > 110899 Medical Microbiology not elsewhere classified
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
E Expanding Knowledge > 97 Expanding Knowledge > 970103 Expanding Knowledge in the Chemical Sciences
Identification Number or DOI: doi: 10.1021/np100329w
URI: http://eprints.usq.edu.au/id/eprint/8823

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