Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity

Hesse, Deike and Dunn, Mark and Heldmaier, Gerhard and Klingenspor, Martin and Rozman, Jan (2010) Behavioural mechanisms affecting energy regulation in mice prone or resistant to diet-induced obesity. Physiology and Behavior, 99 (3). pp. 370-380. ISSN 0031-9384

Abstract

We investigated inbred SWR/J and AKR/J mice, two established models for different susceptibility to dietinduced obesity (DIO), to scrutinize the contribution of physical activity and energy assimilation to the etiology of developing obesity. Body mass gain and body composition of mice fed a high-energy (HE) or a low caloric control diet were monitored. In parallel, assimilated energy, locomotor activity and thermoregulatory behaviour were measured. Activity was continuously registered by radio telemetry and, in addition, Open Field (OF) behaviour was used as a quick screening tool for spontaneous activity before and after the feeding trial. Energy assimilation was increased in both strains on HE (AKR/J: +60.7% and SWR/J: +42.8%) but only in AKR/J, body mass (+8.1%) and fat mass (+40.7%) were significantly elevated. As a trend, total home cage activity was increased and was more scattered in SWR/J. Interestingly, HE stimulated of activity only in SWR/J in the second trial at the end of the feeding experiment. The spatial pattern of OF activity also differed between strains with obese mice avoiding the core area. Under housing conditions, nest building behaviour was more pronounced in AKR/J. To further evaluate OF behaviour as a marker for spontaneous activity an obese mouse line was investigated. Mice lacking the leptin receptor (db/db) showed already before the onset of obesity lowest activity levels in OF. Adjustment of energy intake, higher activity levels and energy consuming thermoregulatory behaviour are mechanisms employed by SWR/J mice to dissipate excess energy as a defence against the onset of obesity. Therefore our results deciphering mechanisms of DIO-sensitivity in mice contribute to the understanding of inter-individual differences in body weight development in an adipogenic environment.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held.
Depositing User: epEditor USQ
Faculty / Department / School: Historic - Faculty of Engineering and Surveying - No Department
Date Deposited: 06 Jul 2010 01:45
Last Modified: 27 Jul 2014 12:38
Uncontrolled Keywords: AKR/J; SWR/J; NEAT; inbred mouse strain; energy balance; obesity; DXA; open field; diet-induced; high caloric diet
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
17 Psychology and Cognitive Sciences > 1702 Cognitive Sciences > 170202 Decision Making
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
Socio-Economic Objective (SEO2008): C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920401 Behaviour and Health
Identification Number or DOI: doi: 10.1016/j.physbeh.2009.12.001
URI: http://eprints.usq.edu.au/id/eprint/8350

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