Zeiler, Irmgard and Langlands, Trevor and Murray, John M. and Ritter, Alison (2010) Optimal targeting of hepatitis C virus treatment among injecting drug users to those not enrolled in methadone maintenance programs. Drug and Alcohol Dependence, 110 (3). pp. 228-233. ISSN 0376-8716
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Background: This work used mathematical modelling to explore effective policy for Hepatitis C virus (HCV) treatment in Australia in the context of methadone maintenance treatment (MMT).
Method: We consider two models to depict HCV in the population of injecting drug users (IDU) within Australia. The first model considers the IDU population as a whole. The second model includes separate components for those that are or are not enrolled in MMT. The impact of different levels of HCV treatment and its allocation dependent on MMT status were then determined in terms of the steady state levels of each of these models.
Results: Although increasing levels of HCV treatment decrease chronic infection prevalence, initially numbers
of acutely infected can rise. This is caused by the high rate of reinfection. We find that no matter the extent of HCV treatment, HCV prevalence cannot be eliminated without limiting risk behaviour. Assuming equal adherence to HCV therapy between MMT and non-MMT, over 84% of HCV treatment should be allocated to those not in MMT. Only if adherence to HCV therapy in non-MMT patients falls below 44% of that in MMT then treatment should be preferentially directed to those in MMT.
Conclusions: Contrary to generally held beliefs regarding HCV treatment the majority of therapy should be allocated to those that are still actively injecting. This is due to rates of reinfection and to the high turnover of individuals in MMT. Higher adherence to HCV therapy in MMT would need to be achieved before this changed.
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|Item Type:||Article (Commonwealth Reporting Category C)|
|Publisher:||Elsevier Ireland Ltd.|
|Item Status:||Live Archive|
|Additional Information (displayed to public):||Author version deposited in accordance with the copyright policy of the publisher.|
|Depositing User:||Dr Trevor Langlands|
|Faculty / Department / School:||Historic - Faculty of Sciences - Department of Maths and Computing|
|Date Deposited:||18 Sep 2010 12:12|
|Last Modified:||02 Jul 2013 23:53|
|Uncontrolled Keywords:||hepatitis C modelling; mathematical modelling; methadone treatment|
|Fields of Research (FoR):||01 Mathematical Sciences > 0101 Pure Mathematics > 010109 Ordinary Differential Equations, Difference Equations and Dynamical Systems
01 Mathematical Sciences > 0102 Applied Mathematics > 010202 Biological Mathematics
11 Medical and Health Sciences > 1103 Clinical Sciences > 110309 Infectious Diseases
|Identification Number or DOI:||doi: 10.1016/j.drugalcdep.2010.03.006|
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