Endurance exercise and DNA stability: is there a link to duration and intensity?

Reichhold, Stefanie and Neubauer, Oliver and Bulmer, Andrew C. and Knasmuller, Siegfried and Wagner, Karl-Heinz (2009) Endurance exercise and DNA stability: is there a link to duration and intensity? Mutation Research - Reviews, 682 (1). pp. 28-38. ISSN 1383-5742

Abstract

It is commonly accepted that regular moderate intensity physical activity reduces the risk of developing many diseases. Counter intuitively, however, evidence also exists for oxidative stress resulting from acute and strenuous exercise. Enhanced formation of reactive oxygen and nitrogen species may lead to oxidatively modified lipids, proteins and nucleic acids and possibly disease. Currently, only a few studies have investigated the influence of exercise on DNA stability and damage with conflicting results, small study groups and the use of different sample matrices or methods and result units. This is the first review to address the effect of exercise of various intensities and durations on DNA stability, focusing on human population studies. Furthermore, this article describes the principles and limitations of commonly used methods for the assessment of oxidatively modified DNA and DNA stability. This review is structured according to the type of exercise conducted (field or laboratory based) and the intensity performed (i.e. competitive ultra/endurance exercise or maximal tests until exhaustion). The findings presented here suggest that competitive ultra-endurance exercise (>4 h) does not induce persistent DNA damage. However, when considering the effects of endurance exercise (<4 h), no clear conclusions could be drawn. Laboratory studies have shown equivocal results (increased or no oxidative stress) after endurance or exhaustive exercise. To clarify which components of exercise participation (i.e. duration, intensity and training status of subjects) have an impact on DNA stability and damage, additional carefully designed studies combining the measurement of DNA damage, gene expression and DNA repair mechanisms before, during and after exercise of differing intensities and durations are required.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held.
Depositing User: Ms Debbie White
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 06 Jul 2010 11:45
Last Modified: 03 Aug 2014 07:33
Uncontrolled Keywords: biological markers; DNA damage; physical activity; ultra-endurance exercise; physical fitness; exercise intensity
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1106 Human Movement and Sports Science > 110602 Exercise Physiology
06 Biological Sciences > 0604 Genetics > 060407 Genome Structure and Regulation
11 Medical and Health Sciences > 1103 Clinical Sciences > 110311 Medical Genetics (excl. Cancer Genetics)
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: doi: 10.1016/j.mrrev.2009.02.002
URI: http://eprints.usq.edu.au/id/eprint/7886

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