Increased generation of platelet-derived microparticles following percutaneous transluminal coronary angioplasty

Craft, Judy A. and Marsh, Neville A. (2003) Increased generation of platelet-derived microparticles following percutaneous transluminal coronary angioplasty. Blood Coagulation and Fibrinolysis: International Journal in Haemostasis and Thrombosis, 14 (8). pp. 719-728. ISSN 0957-5235


Platelet-derived microparticles that are produced during platelet activation bind to traumatized endothelium. Such endothelial injury occurs during percutaneous transluminal coronary angioplasty. Approximately 20% of these patients subsequently develop restenosis, although this is improved by treatment with the anti-platelet glycoprotein IIb/IIIa receptor drug abciximab. As platelet activation occurs during angioplasty, it is likely that platelet-derived microparticles may be produced and hence contribute to restenosis. This study population consisted of 113 angioplasty patients, of whom 38 received abciximab. Paired peripheral arterial blood samples were obtained following heparinization and subsequent to all vessel manipulation. Platelet-derived microparticles were identified using an anti-CD61 (glycoprotein IIIa) fluorescence-conjugated antibody and flow cytometry. Baseline clinical characteristics between patient groups were similar. The level of platelet-derived microparticles increased significantly following angioplasty in the group without abciximab (paired t test, P 0.019). However, there was no significant change in the level of platelet-derived microparticles following angioplasty in patients who received abciximab, despite requiring more complex angioplasty procedures. In this study, we have demonstrated that the level of platelet-derived microparticles increased during percutaneous transluminal coronary angioplasty, with no such increase with abciximab treatment. The increased platelet-derived microparticles may adhere to traumatized endothelium,contributing to re-occlusion of the arteries, but this remains to be determined.

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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held.
Depositing User: Ms Debbie White
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 01 May 2010 03:33
Last Modified: 02 Jul 2013 23:51
Uncontrolled Keywords: platelet-derived microparticles, blood platelets, flow cytometry, angioplasty, transluminal, percutaneous coronary, platelet aggregation inhibitors
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110202 Haematology
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences

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