Muhlhausler, B. S. and Adam, C. L. and Marrocco, E. M. and Findlay, P. A. and Roberts, C. T. and McFarlane, J. R. and Kauter, K. G. and McMillen, I. C. (2005) Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. The Journal of Physiology, 565 (1). pp. 185-195. ISSN 0022-3751
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Official URL: http://jp.physoc.org/content/565/1/185
Identification Number or DOI: doi: 10.1113jphysiol.2004.079079
In the present study, our aim was to determine whether intrafetal glucose infusion increases fetal adiposity, synthesis and secretion of leptin and regulates gene expression of the 'appetite regulatory' neuropeptides neuropeptide Y (NPY), agouti-related peptide (AGRP. pro-opiomelanocortin (POMC)and cocaine and amphetamine-regulated transcript (CART) and receptors (leptin receptor (OB-Rb) and melancortin 3 receptor (MC3R))within the fetal hypothalamus. These findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Author version not held.|
|Uncontrolled Keywords:||neuropeptides; fetal hypothalamus; adipose tissue; appetite regulation; blood glucose; foetal blood|
|Fields of Research (FOR2008):||06 Biological Sciences > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified|
11 Medical and Health Sciences > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified
11 Medical and Health Sciences > 1116 Medical Physiology > 111699 Medical Physiology not elsewhere classified
|Socio-Economic Objective (SEO2008):||E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences|
|Deposited On:||14 May 2010 21:31|
|Last Modified:||18 Sep 2012 12:48|
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