Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation

Muhlhausler, B. S. and Adam, C. L. and Marrocco, E. M. and Findlay, P. A. and Roberts, C. T. and McFarlane, J. R. and Kauter, K. G. and McMillen, I. C. (2005) Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. The Journal of Physiology, 565 (1). pp. 185-195. ISSN 0022-3751

Abstract

In the present study, our aim was to determine whether intrafetal glucose infusion increases fetal adiposity, synthesis and secretion of leptin and regulates gene expression of the 'appetite regulatory' neuropeptides neuropeptide Y (NPY), agouti-related peptide (AGRP. pro-opiomelanocortin (POMC)and cocaine and amphetamine-regulated transcript (CART) and receptors (leptin receptor (OB-Rb) and melancortin 3 receptor (MC3R))within the fetal hypothalamus. These findings demonstrate that increased circulating glucose and insulin regulate gene expression of the neuropeptides within the fetal hypothalamus that are part of the neural network regulating energy balance in adult life.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held.
Depositing User: Ms Debbie White
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 14 May 2010 11:31
Last Modified: 17 Sep 2013 06:46
Uncontrolled Keywords: neuropeptides; fetal hypothalamus; adipose tissue; appetite regulation; blood glucose; foetal blood
Fields of Research (FOR2008): 06 Biological Sciences > 0608 Zoology > 060803 Animal Developmental and Reproductive Biology
07 Agricultural and Veterinary Sciences > 0702 Animal Production > 070204 Animal Nutrition
07 Agricultural and Veterinary Sciences > 0702 Animal Production > 070206 Animal Reproduction
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Identification Number or DOI: doi: 10.1113jphysiol.2004.079079
URI: http://eprints.usq.edu.au/id/eprint/7763

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