Leptin alters the structural and functional characteristics of adipose tissue before birth

Yuen, B. S. J. and Owens, P. C. and Muhlhausler, B. S. and Roberts, C. T. and Symonds, M. E. and Keisler, D. H. and McFarlane, J. R. and Kauter, K. G. and Evens, Y. and McMillen, I. C. (2003) Leptin alters the structural and functional characteristics of adipose tissue before birth. The FASEB Journal, 17 (9). pp. 1102-1104. ISSN 0892-6638

Abstract

This study aimed to determine for the first time whether leptin can act to alter the structural and functional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline was infused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation (term=147±3 days). Circulating leptin concentrations were increased approximately four- to fivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion of smaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associated with a significant increase in the proportion of multilocular tissue and a significant decrease in the proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance of leptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was a positive correlation between the relative abundance of leptin mRNA and the proportion of unilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher (P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held.
Depositing User: Ms Debbie White
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 09 May 2010 11:19
Last Modified: 18 Oct 2013 02:03
Uncontrolled Keywords: fetus; lipid; UCP1; leptin
Fields of Research (FOR2008): 06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified
07 Agricultural and Veterinary Sciences > 0702 Animal Production > 070204 Animal Nutrition
07 Agricultural and Veterinary Sciences > 0702 Animal Production > 070206 Animal Reproduction
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences
Identification Number or DOI: doi: 10.1096/fj.02-0756fje
URI: http://eprints.usq.edu.au/id/eprint/7755

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