Inflammatory lipid mediators in adipocyte function and obesity

Iyer, Abishek and Prins, Johannes B. and Fairlie, David P. and Hammock, Bruce D. and Brown, Lindsay (2010) Inflammatory lipid mediators in adipocyte function and obesity. Nature Reviews Endocrinology, 6 (2). pp. 71-82. ISSN 1759-5029

Abstract

Survival of multicellular organisms depends on their ability to fight infection, metabolize nutrients, and store energy for times of need. Unsurprisingly, therefore, immunoregulatory and metabolic mechanisms interact in human conditions such as obesity. Both infiltrating immunoinflammatory cells and adipocytes play critical roles in the modulation of metabolic homeostasis, so it is important to understand factors that regulate both adipocyte and immune cell function. A currently favored paradigm for obesity-associated metabolic dysfunction is that chronic macronutrient and/or lipid overload (associated with adiposity) induces cellular stress that initiates and perpetuates an inflammatory cycle and pathophysiological signaling of immunoinflammatory cells and adipocytes. Many lipid mediators exert their biological effects by binding to cognate receptors, such as G-protein-coupled receptors and Toll-like receptors. This process is tightly regulated under normal physiological conditions, and any disruption can initiate disease processes. Observations that cellular lipid loading (associated with adiposity) initiates inflammatory events has encouraged studies on the role of lipid mediators. In this review, we speculate that lipid mediators act on important immune receptors to induce low-grade tissue inflammation, which leads to adipocyte and metabolic dysfunction.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author version not held.
Depositing User: Professor Lindsay Brown
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 29 Aug 2010 07:31
Last Modified: 02 Jul 2013 23:50
Uncontrolled Keywords: adipocytes; immune cell function; lipid mediators
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1103 Clinical Sciences > 110306 Endocrinology
11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids
11 Medical and Health Sciences > 1107 Immunology > 110704 Cellular Immunology
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: doi: 10.1038/nrendo.2009.264
URI: http://eprints.usq.edu.au/id/eprint/7745

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