Genetic contribution to individual variation in binocular rivalry rate

Miller, Steven M. and Hansell, Narelle K. and Ngo, Trung T. and Liu, Guang B. and Pettigrew, John D. and Martin, Nicholas G. and Wright, Margaret J. (2010) Genetic contribution to individual variation in binocular rivalry rate. Proceedings of the National Academy of Sciences of USA, 107 (6). pp. 2664-2668. ISSN 0027-8424

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Abstract

Binocular rivalry occurs when conflicting images are presented in corresponding locations of the two eyes. Perception alternates between the images at a rate that is relatively stable within individuals but that varies widely between individuals. The determinants of this variation are unknown. In addition, slow binocular rivalry has been demonstrated in bipolar disorder, a psychiatric condition with high heritability. The present study therefore examined whether there is a genetic contribution to individual variation in binocular rivalry rate. We employed the twin method and studied both monozygotic (MZ) twins (n = 128 pairs) who are genetically identical, and dizygotic (DZ) twins (n = 220 pairs) who share roughly half their genes. MZ and DZ twin correlations for binocular rivalry rate were 0.51 and 0.19, respectively. The bestfitting genetic model showed 52% of the variance in binocular rivalry rate was accounted for by additive genetic factors. In contrast, nonshared environmental influences accounted for 18% of the variance, with the remainder attributed to measurement error. This study therefore demonstrates a substantial genetic contribution to individual variation in binocular rivalry rate. The results support the vigorous pursuit of genetic and molecular studies of binocular rivalry and further characterization of slow binocular rivalry as an endophenotype for bipolar disorder.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Authors' version of paper deposited in accordance with the copyight policy of the publisher (PNAS).
Depositing User: Dr Guang Liu
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 28 Oct 2010 10:57
Last Modified: 08 Aug 2014 01:06
Uncontrolled Keywords: perceptual rivalry; bipolar disorder; endophenotype; genetics; twins
Fields of Research (FOR2008): 06 Biological Sciences > 0604 Genetics > 060410 Neurogenetics
02 Physical Sciences > 0205 Optical Physics > 020599 Optical Physics not elsewhere classified
11 Medical and Health Sciences > 1113 Ophthalmology and Optometry > 111303 Vision Science
Socio-Economic Objective (SEO2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders
Identification Number or DOI: doi: 10.1073/pnas.0912149107
URI: http://eprints.usq.edu.au/id/eprint/7366

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