L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats

Fenning, Andrew and Harrison, Glenn and Rose'Meyer, Roselyn and Hoey, Andrew and Brown, Lindsay (2005) L-Arginine attenuates cardiovascular impairment in DOCA-salt hypertensive rats. American Journal of Physiology: Heart and Circulatory Physiology, 289 (4). H1408-H1416. ISSN 0363-6135

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Abstract

Nitric oxide (NO) is essential for normal function of the cardiovascular system. This study has determined whether chronic administration of L-arginine, the biological precursor of NO, attenuates the development of structural and functional changes in hearts and blood vessels of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Uninephrectomized rats treated with DOCA (25 mg every 4th day sc) and 1% NaCl in the drinking water for 4 wk were treated with L-arginine (5% in food, 3.4 plus/minus 0.3 g per kg body wt-1 per day-1). Changes in cardiovascular structure and function were determined by echocardiography, microelectrode studies, histology, and studies in isolated hearts and thoracic aortic rings. DOCA-salt hypertensive rats developed hypertension, left ventricular hypertrophy with increased left ventricular wall thickness and decreased ventricular internal diameter, increased inflammatory cell infiltration, increased ventricular interstitial and perivascular collagen deposition, increased passive diastolic stiffness, prolonged action potential duration, increased oxidative stress, and inability to increase purine efflux in response to an increased workload. L-Arginine markedly attenuated or prevented these changes and also normalized the reduced efficacy of norepinephrine and acetylcholine in isolated thoracic aortic rings of DOCA-salt hypertensive rats. This study suggests that a functional NO deficit in blood vessels and heart due to decreased NO synthase activity or increased release of reactive oxygen species such as superoxide may be a key change initiating many aspects of the cardiovascular impairment observed in DOCA-salt hypertensive rats. These changes can be prevented or attenuated by administration of L-arginine.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published version made not accessible due to publisher copyright policy. Full article available only on Publisher website as above. After October 2006 it may also be available at Pubmed Central http://www.pubmedcentral.nih.gov/
Depositing User: epEditor USQ
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 11 Oct 2007 00:21
Last Modified: 02 Jul 2013 22:32
Uncontrolled Keywords: eoxycorticosterone acetate; oxidative stress; remodeling; collagen
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1116 Medical Physiology > 111603 Systems Physiology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
Identification Number or DOI: doi: 10.1152/ajpheart.00140.2005
URI: http://eprints.usq.edu.au/id/eprint/450

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