In vitro effect of canine hyperimmune sera on TNFa activity

Kotiw, Michael and Shiels, I. A. and Wilson, R. P. and Reeve-Johnson, Lloyd (2006) In vitro effect of canine hyperimmune sera on TNFa activity. Journal of Veterinary Pharmacology and Therapeutics, 29 (Su. pp. 100-101. ISSN 0140-7783

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Abstract

[Introduction]: Septic shock in dogs is caused by cardiovascular and vasomotor failure associated with an uncontrolled intrinsic release of inflammatory mediators [1–5]. The syndrome is characterized by cardiovascular dysfunction, vascular permeability alterations, pulmonary oedema and tissue hypoxia resulting from microthrombi which may culminate in disseminated intravascular coagulation and catastrophic multiple organ failure [6,7]. Systemic bacterial infection, particularly by Gram-negative enterobacteria, haemorrhagic trauma, gastric dilation/volvulus and pancreatitis are the major underlying causes leading tosepsis [8,9]. Because of haemodynamic instability and associated hypovolemia, fluid replacement therapy is generally applied to restore effective circulating volume. The use of fresh frozen plasma has been recommended in cases of coagulopathies as it has been recognized to assist restoration of haemodynamic stability [1,5,10,11]. There is increasing evidence that the drivers of the haemodynamic instability are inflammatory mediators (particularly TNFa) activated primarily by bacterial endotoxin [3,4,12,13].


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Author's version deposited in accordance with the copyright policy of the publisher.
Depositing User: Assoc Prof Mike Kotiw
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 06 Aug 2008 11:14
Last Modified: 02 Jul 2013 22:55
Uncontrolled Keywords: septic shock; dogs
Fields of Research (FOR2008): 07 Agricultural and Veterinary Sciences > 0707 Veterinary Sciences > 070703 Veterinary Diagnosis and Diagnostics
07 Agricultural and Veterinary Sciences > 0707 Veterinary Sciences > 070799 Veterinary Sciences not elsewhere classified
Identification Number or DOI: doi: 10.1111/j.1365-2885.2006.00761.x
URI: http://eprints.usq.edu.au/id/eprint/3665

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