Xanthones from a microfungus of the genus Xylaria

Healy, Peter C. and Hocking, Ailsa and Tran-Dinh, Nai and Pitt, John I. and Shivas, Roger G. and Mitchell, Jennifer K. and Kotiw, Mike and Davis, Rohan A. (2004) Xanthones from a microfungus of the genus Xylaria. Phytochemistry, 65 (16). pp. 2373-2378. ISSN 0031-9422

Abstract

Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1–3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens.


Statistics for USQ ePrint 3620
Statistics for this ePrint Item
Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: © 2004 Elsevier Ltd. All rights reserved. Deposited in accordance with the copyright policy of the publisher. Awaiting Author's version.
Depositing User: Assoc Prof Mike Kotiw
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 23 Jan 2008 01:30
Last Modified: 13 Sep 2013 03:22
Uncontrolled Keywords: microfungus; Xylaria sp.; rainforest tree; glochidion ferdinandi; natural products; secondary metabolites; Xanthone
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics
06 Biological Sciences > 0605 Microbiology > 060505 Mycology
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI: doi: 10.1016/j.phytochem.2004.07.019
URI: http://eprints.usq.edu.au/id/eprint/3620

Actions (login required)

View Item Archive Repository Staff Only