Healy, Peter C. and Hocking, Ailsa and Tran-Dinh, Nai and Pitt, John I. and Shivas, Roger G. and Mitchell, Jennifer K. and Kotiw, Mike and Davis, Rohan A. (2004) Xanthones from a microfungus of the genus Xylaria. Phytochemistry, 65 (16). pp. 2373-2378. ISSN 0031-9422
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Official URL: http://www.sciencedirect.com/science/journal/00319422
Identification Number or DOI: doi: 10.1016/j.phytochem.2004.07.019
Abstract
Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1–3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens.
| Item Type: | Article (Commonwealth Reporting Category C) |
|---|---|
| Additional Information: | Deposited in acocrdance with the copyright policy of the publisher. Awaiting Author's version. |
| Uncontrolled Keywords: | microfungus; Xylaria sp.; rainforest tree; glochidion ferdinandi; natural products; secondary metabolites; Xanthone |
| Fields of Research (FOR2008): | 11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics 06 Biological Sciences > 0605 Microbiology > 060505 Mycology |
| Subjects: | 320000 Medical and Health Sciences > 320500 Pharmacology and Pharmaceutical Sciences |
| Socio-Economic Objective (SEO2008): | E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences |
| ID Code: | 3620 |
| Deposited By: | |
| Deposited On: | 23 Jan 2008 11:30 |
| Last Modified: | 26 Jul 2012 11:29 |
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