Healy, Peter C. and Hocking, Ailsa and Tran-Dinh, Nai and Pitt, John I. and Shivas, Roger G. and Mitchell, Jennifer K. and Kotiw, Mike and Davis, Rohan A. (2004) Xanthones from a microfungus of the genus Xylaria. Phytochemistry, 65 (16). pp. 2373-2378. ISSN 0031-9422
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Official URL: http://www.sciencedirect.com/science/journal/00319422
Identification Number or DOI: doi: 10.1016/j.phytochem.2004.07.019
Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1–3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Deposited in acocrdance with the copyright policy of the publisher. Awaiting Author's version.|
|Uncontrolled Keywords:||microfungus; Xylaria sp.; rainforest tree; glochidion ferdinandi; natural products; secondary metabolites; Xanthone|
|Fields of Research (FOR2008):||11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics|
06 Biological Sciences > 0605 Microbiology > 060505 Mycology
|Subjects:||320000 Medical and Health Sciences > 320500 Pharmacology and Pharmaceutical Sciences|
|Socio-Economic Objective (SEO2008):||E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences|
|Deposited On:||23 Jan 2008 11:30|
|Last Modified:||26 Jul 2012 11:29|
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