Xu, Youhong and Chen, Austen Y. and Fry, Scott R. and Barrow, Russell A. and Marshall, Raymond L. and Mukkur, T. K. S. (2007) Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide. International Immunopharmacology, 7 (4). pp. 515-523. ISSN 1567-5769
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Official URL: http://dx.doi.org/10.1016/j.intimp.2006.12.008
Identification Number or DOI: doi: 1016/j.intimp.2006.12.008
[Abstract]: Gavage of mice, immunised with an inactivated S. typhimurium vaccine, with Andrographis paniculata extract [APE] or andrographolide [AND] resulted in an enhancement of Salmonella-specific antibody response and induction of cell-mediated response against salmonellosis. Mice were vaccinated with either one or two doses of killed S. typhimurium vaccine and fed two different quantities of APE or AND, for 14 days in mice immunised with one dose of the vaccine, and for 28 days in mice immunised with two doses of vaccine, respectively. Both APE and AND were found to enhance IgG antibody levels against S. typhimurium, the enhancement being statistically significant in mice receiving two doses of the vaccine. Splenocyte cultures, prepared from mice immunised with the killed Salmonella vaccine and treated with APE or AND, showed a remarkable increase in the production IFN-γ following stimulation with the bacterial lysate, indicating an induction of Salmonella-specific cell-mediated response/immune response.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Deposited in accordance with the copyright policy of the publisher. Awaiting paper (Author's version) from author.|
|Uncontrolled Keywords:||Andrographis paniculata; andrographolide; immunomodulatory; antibody response; cell-mediated immunity|
|Fields of Research (FOR2008):||11 Medical and Health Sciences > 1107 Immunology > 110704 Cellular Immunology|
|Subjects:||320000 Medical and Health Sciences > 320200 Immunology > 320202 Cellular Immunology|
|Socio-Economic Objective (SEO2008):||UNSPECIFIED|
|Deposited On:||18 Apr 2008 11:58|
|Last Modified:||30 Jan 2012 11:43|
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