Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide

Xu, Youhong and Chen, Austen Y. and Fry, Scott R. and Barrow, Russell A. and Marshall, Raymond L. and Mukkur, T. K. S. (2007) Modulation of immune response in mice immunised with an inactivated Salmonella vaccine and gavaged with Andrographis paniculata extract or andrographolide. International Immunopharmacology, 7 (4). pp. 515-523. ISSN 1567-5769

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Abstract

[Abstract]: Gavage of mice, immunised with an inactivated S. typhimurium vaccine, with Andrographis paniculata extract [APE] or andrographolide [AND] resulted in an enhancement of Salmonella-specific antibody response and induction of cell-mediated response against salmonellosis. Mice were vaccinated with either one or two doses of killed S. typhimurium vaccine and fed two different quantities of APE or AND, for 14 days in mice immunised with one dose of the vaccine, and for 28 days in mice immunised with two doses of vaccine, respectively. Both APE and AND were found to enhance IgG antibody levels against S. typhimurium, the enhancement being statistically significant in mice receiving two doses of the vaccine. Splenocyte cultures, prepared from mice immunised with the killed Salmonella vaccine and treated with APE or AND, showed a remarkable increase in the production IFN-γ following stimulation with the bacterial lysate, indicating an induction of Salmonella-specific cell-mediated response/immune response.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Deposited in accordance with the copyright policy of the publisher. Awaiting paper (Author's version) from author.
Depositing User: Ms Debbie White
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 18 Apr 2008 01:58
Last Modified: 30 Jan 2012 01:43
Uncontrolled Keywords: Andrographis paniculata; andrographolide; immunomodulatory; antibody response; cell-mediated immunity
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1107 Immunology > 110704 Cellular Immunology
Identification Number or DOI: doi: 1016/j.intimp.2006.12.008
URI: http://eprints.usq.edu.au/id/eprint/2865

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