Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats

Chan, Vincent and Hoey, Andrew and Brown, Lindsay (2006) Improved cardiovascular function with aminoguanidine in DOCA-salt hypertensive rats. British Journal of Pharmacology, 148 (7). pp. 902-908. ISSN 0007-1188

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Abstract

[Summary]: 1. The ability of aminoguanidine, an inhibitor of collagen cross-linking, to prevent changes in cardiac and vascular structure and function has been determined in the DOCA-salt hypertensive rat as a model of the cardiovascular remodelling observed in chronic human hypertension. 2. Uninephrectomised rats (UNX) administered DOCA (25mg every 4th day sc) and 1% NaCl in drinking water for 28 days developed cardiovascular remodelling shown as systolic hypertension, left ventricular hypertrophy, increased thoracic aortic and left ventricular wall thickness, increased left ventricular inflammatory cell infiltration together with increased interstitial collagen and increased passive diastolic stiffness, impaired contractility, prolongation of the action potential duration and vascular dysfunction.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Deposited in accordance with the copyright policy of the publisher.
Depositing User: Ms Debbie White
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 11 Oct 2007 01:13
Last Modified: 02 Jul 2013 22:46
Uncontrolled Keywords: aminoguanidine; collagen cross-linking; DOCA-salt rats; hypertension; remodelling
Fields of Research (FOR2008): 06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified
Identification Number or DOI: doi: 10.1038/sj.bjp.0706801
URI: http://eprints.usq.edu.au/id/eprint/2733

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