Panchal, Sunil K. and Poudyal, Hemant and Waanders, Jennifer and Brown, Lindsay (2012) Coffee extract attenuates changes in cardiovascular and hepatic structure and function without decreasing obesity in high-carbohydrate, high-fat diet-fed male rats. The Journal of Nutrition, 142 (4). pp. 690-697. ISSN 0022-3166
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Official URL: http://jn.nutrition.org/content/142/4/690
Identification Number or DOI: doi: 10.3945/jn.111.153577
Coffee, a rich source of natural products, including caffeine, chlorogenic acid, and diterpenoid alcohols, has been part of the human diet since the 15th century. In this study, we characterized the effects of Colombian coffee extract (CE), which contains high concentrations of caffeine and diterpenoids, on a rat model of human metabolic syndrome. The 8–9 wk old male Wistar rats were divided into four groups. Two groups of rats were fed a corn starch-rich diet whereas the other two groups were given a high-carbohydrate, high-fat diet with 25% fructose in drinking water for 16 wk. One group fed each diet was supplemented with 5% aqueous CE for the final 8 wk of this protocol. The corn starch diet contained ~68% carbohydrates mainly as polysaccharides, whereas the high-carbohydrate, high-fat diet contained ~68% carbohydrates mainly as fructose and sucrose together with 24% fat, mainly as saturated and monounsaturated fat from beef tallow. The high-carbohydrate, high-fat diet-fed rats showed the symptoms of metabolic syndrome leading to cardiovascular remodeling and nonalcoholic fatty liver disease. CE supplementation attenuated impairment in glucose tolerance, hypertension, cardiovascular remodeling, and nonalcoholic fatty liver disease without changing abdominal obesity and dyslipidemia. This study suggests that CE can attenuate diet-induced changes in the structure and function of the heart and the liver without changing the abdominal fat deposition.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Permanent restricted access to published version, due to publisher's copyright policy (American Society for Nutrition).|
|Uncontrolled Keywords:||abdominal obesity; albumin blood level; animal tissue; bilirubin blood level; blood vessel reactivity; carbohydrate diet; cholesterol blood level; coffee; concentration (parameters); dyslipidemia; fatty liver; glucose blood level; glucose tolerance; heart ventricle remodeling; heart weight|
|Fields of Research (FOR2008):||11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine|
06 Biological Sciences > 0606 Physiology > 060604 Comparative Physiology
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
|Socio-Economic Objective (SEO2008):||E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences|
|Deposited On:||03 Dec 2012 21:45|
|Last Modified:||18 Apr 2013 11:49|
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