Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats

Panchal, Sunil K. and Ward, Leigh and Brown, Lindsay (2013) Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. European Journal of Nutrition , 52 (2). pp. 559-568. ISSN 1436-6207

Abstract

Background: Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-induced rat model of metabolic syndrome. Methods: Eight-to nine-week-old male Wistar rats were divided into four groups for 16-week feeding with cornstarch diet (C), cornstarch diet supplemented with ellagic acid (CE), high-carbohydrate, high-fat diet (H) and high carbohydrate, high-fat diet supplemented with ellagic acid (HE). CE and HE rats were given 0.8 g/kg ellagic acid in food from week 8 to 16 only. At the end of 16 weeks, cardiovascular, hepatic and metabolic parameters along with protein levels of Nrf2, NF-jB and CPT1 in the heart and the liver were characterised. Results: High-carbohydrate, high-fat diet-fed rats developed cardiovascular remodelling, impaired ventricular function, impaired glucose tolerance, non-alcoholic fatty liver disease with increased protein levels of NF-jB and decreased protein levels of Nrf2 and CPT1 in the heart and the liver. Ellagic acid attenuated these diet-induced symptoms of metabolic syndrome with normalisation of protein levels of Nrf2, NF-jB and CPT1. Conclusions: Ellagic acid derived from nuts and fruits such as raspberries and pomegranates may provide a useful dietary supplement to decrease the characteristic changes in metabolism and in cardiac and hepatic structure and function induced by a high-carbohydrate, high-fat diet by suppressing oxidative stress and inflammation.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Published online 27 April 2012. Permanent restricted access to Published version in accordance with the copyright policy of the publisher.
Depositing User: epEditor USQ
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 06 Sep 2012 00:14
Last Modified: 08 Jul 2013 23:05
Uncontrolled Keywords: cardiovascular remodelling; ellagic acid; metabolic syndrome; non-alcoholic fatty liver disease; obesity
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111102 Dietetics and Nutrigenomics
10 Technology > 1004 Medical Biotechnology > 100499 Medical Biotechnology not elsewhere classified
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
Identification Number or DOI: doi: 10.1007/s00394-012-0358-9
URI: http://eprints.usq.edu.au/id/eprint/21843

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