Panchal, Sunil K. and Ward, Leigh and Brown, Lindsay (2012) Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. European Journal of Nutrition . ISSN 1436-6207 (In Press)
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Identification Number or DOI: doi: 10.1007/s00394-012-0358-9
Background: Fruits and nuts may prevent or reverse common human health conditions such as obesity, diabetes and hypertension; together, these conditions are referred to as metabolic syndrome, an increasing problem. This study has investigated the responses to ellagic acid, present in many fruits and nuts, in a diet-induced rat model of metabolic syndrome. Methods: Eight-to nine-week-old male Wistar rats were divided into four groups for 16-week feeding with cornstarch diet (C), cornstarch diet supplemented with ellagic acid (CE), high-carbohydrate, high-fat diet (H) and high carbohydrate, high-fat diet supplemented with ellagic acid (HE). CE and HE rats were given 0.8 g/kg ellagic acid in food from week 8 to 16 only. At the end of 16 weeks, cardiovascular, hepatic and metabolic parameters along with protein levels of Nrf2, NF-jB and CPT1 in the heart and the liver were characterised. Results: High-carbohydrate, high-fat diet-fed rats developed cardiovascular remodelling, impaired ventricular function, impaired glucose tolerance, non-alcoholic fatty liver disease with increased protein levels of NF-jB and decreased protein levels of Nrf2 and CPT1 in the heart and the liver. Ellagic acid attenuated these diet-induced symptoms of metabolic syndrome with normalisation of protein levels of Nrf2, NF-jB and CPT1. Conclusions: Ellagic acid derived from nuts and fruits such as raspberries and pomegranates may provide a useful dietary supplement to decrease the characteristic changes in metabolism and in cardiac and hepatic structure and function induced by a high-carbohydrate, high-fat diet by suppressing oxidative stress and inflammation.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Published online 27 April 2012. Permanent restricted access to ArticleFirst version in accordance with the copyright policy of the publisher.|
|Uncontrolled Keywords:||cardiovascular remodelling; ellagic acid; metabolic syndrome; non-alcoholic fatty liver disease; obesity|
|Fields of Research (FOR2008):||11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine|
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111102 Dietetics and Nutrigenomics
10 Technology > 1004 Medical Biotechnology > 100499 Medical Biotechnology not elsewhere classified
|Socio-Economic Objective (SEO2008):||E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences|
|Deposited On:||06 Sep 2012 10:14|
|Last Modified:||15 Mar 2013 15:02|
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