Li, Mao and Li, Yan and Wen, Peng (Paul) (2012) Tumor-induced effects on PO2 distribution in a normal tissue. In: 2012 IEEE-EMBS International Conference on Biomedical and Health Informatics: Global Grand Challenge of Health Informatics (BHI 2012), 2-7 Jan 2012, Hong Kong and Shenzhen, China.
A tumor in a normal tissue will introduce some significant physiological and pathological changes to the adjacent normal tissues. To quantitatively study how the tumor affects the partial oxygen pressure (PO2) distribution in a normal tissue, an improved Krogh’s cylinder model that is more realistic than an assumption of homogeneous PO2 distribution in a certain region is used to describe the oxygen diffusion from a capillary into its surrounding tissue. In this study, a comparison of the oxygen transport in a normal tissue without tumors and with an implanted tumor is presented. The results show that when a tumor is implanted at the upstream part of a capillary, the entire surrounding normal tissue that is located at the downstream part of the capillary suffers from a low level of oxygen, and the PO2 in the normal tissue decreases by an average of 16%. In contrast, a tumor located at the downstream part of a capillary makes a slight impact on the PO2 distribution in the upstream normal tissue. However, in both situations, a part of the tumor mass that is far from the capillary is in the quiescent even necrotic status due to the lack of sufficient supply of oxygen.
|Item Type:||Conference or Workshop Item (Commonwealth Reporting Category E) (Paper)|
|Additional Information:||Permanent restricted access to published version due to publisher copyright policy.|
|Uncontrolled Keywords:||tumor growth; oxygen transport; diffusion; cylinder model|
|Depositing User:||Dr Yan Li|
|Date Deposited:||25 Oct 2012 02:17|
|Last Modified:||03 Jul 2013 01:10|
Actions (login required)
|Archive Repository Staff Only|