Panchal, Sunil K. and Brown, Lindsay (2013) Cardioprotective and hepatoprotective effects of ellagitannins from European oak bark (Quercus petraea L.) extract in rats. European Journal of Nutrition, 52 (1). pp. 397-408. ISSN 1436-6207
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Official URL: http://www.springerlink.com/content/b3715t87l7543071/
Identification Number or DOI: doi: 10.1007/s00394-011-0277-1
BACKGROUND: Red wine contains many potentially bioactive polyphenols including resveratrol, catechins, anthocyanins and flavonoids as well as tannins derived from oak during maturation. This study examined the effects of a mixture of ellagitannins from oak bark (Quercus petraea L.) on cardiovascular, metabolic and liver changes in high-carbohydrate, high-fat diet-fed rats and in Spontaneously Hypertensive Rats (SHR). METHODS: First, 8-week-old male Wistar rats were divided into four groups and given either cornstarch diet, cornstarch diet + oak bark extract (0.5 mL/kg food), high-carbohydrate, high-fat diet or high-carbohydrate, high-fat diet + oak bark extract (0.5 mL/kg food) for 16 weeks. Oak bark extract was added to the diets for last 8 weeks of the feeding period. Secondly, SHR aged 42 weeks fed on standard chow diet were divided into two groups with and without oak bark extract treatment for 12 weeks (0.5 mL/kg food). RESULTS: The high-carbohydrate, high-fat diet induced signs of metabolic syndrome along with cardiovascular remodelling and non-alcoholic steatohepatitis. Oak bark extract attenuated the signs of metabolic syndrome in high-carbohydrate, high-fat diet-fed rats and improved the structure and function of the heart and the liver. SHR after oak bark extract treatment for 12 weeks showed lower systolic blood pressure, lower cardiac fibrosis and cardiac stiffness and improved vascular reactivity. CONCLUSIONS: Oak bark extract containing ellagitannins improved cardiovascular, metabolic and liver parameters in these rat models of human disease, suggesting that part of the benefits attributed to red wine may be produced by these ellagitannins.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Published online 21 Nov 2011. Permanent restricted access to Published version in accordance with the copyright policy of the publisher.|
|Uncontrolled Keywords:||obesity; cardiovascular disease; dyslipidaemia; ellagitannins; hypertension|
|Fields of Research (FOR2008):||06 Biological Sciences > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified|
11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
|Socio-Economic Objective (SEO2008):||C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920412 Preventive Medicine|
|Deposited On:||06 Sep 2012 10:11|
|Last Modified:||05 Jun 2013 14:46|
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