Law, P. C. F. and Paton, B. and Liu, G. B. and Ngo, T. T. and Miller, S. M. (2011) Development of a binocular rivalry testing system for large-scale psychiatric and genetic studies. In: 1st Scientific Meeting of Biological Psychiatry Australia, 7-8 Nov 2011, Melbourne, Australia.
Text (Published Version)
Introduction: When different stimuli are presented simultaneously, one to each eye, perceptual alternations occur between each image every few seconds. Such binocular rivalry (BR) has intrigued vision scientists for nearly two centuries and the methods by which BR is presented (usually in small-scale studies) have been mostly confined to expert psychophysicists. It has been demonstrated that BR rate is
slow in bipolar disorder (BD) , a psychiatric condition with high heritability. It has also been shown that BR rate is itself around 50% heritable . These findings have led to establishment of a large-scale multicentre consortium to investigate slow BR rate as an endophenotype for BD . Methods: We describe the development of a prototype, user-friendly BR testing system for use in such large-scale studies and for operation by non-specialised research staff. The system is currently operational, or is in the process of being installed, at the following sites: Monash Alfred Psychiatry Research Centre (P.B. Fitzgerald), The
Geelong Clinic (M. Berk), UNSW (P.B. Mitchell), Cade Clinic (G.S. Malhi), Queensland Institute of Medical Research (N.G. Martin & M.J. Wright), Royal Brisbane & Women’s Hospital (J.G. Scott), Cardiff University (D.J. Smith), and University of Göttingen (T.G. Schulze).
Results: The BR system consists of a PC with enhanced PSU capability and an Eyefinity-enabled video card, which is connected to both a conventional monitor (for data collection/analysis via a single GUI) and a specialised True3Di™ monitor for stimulus presentation. The system also has an accompanying manual which provides step-by-step details of the entire testing procedure.
Conclusions: We have developed a BR testing system that is well suited to largescale psychiatric genetic studies and use by non-specialised research staff. Its ease of operation will facilitate new groups joining the national/international consortium, thus enabling the large Ns required for endophenotype-based GWAS of BR and BD.
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|Item Type:||Conference or Workshop Item (Commonwealth Reporting Category E) (Speech)|
|Publisher:||Biological Psychiatry Australia|
|Item Status:||Live Archive|
|Additional Information (displayed to public):||Abstract only, as displayed here, published in Conference Proceedings.|
|Depositing User:||Dr Guang Liu|
|Faculty / Department / School:||Historic - Faculty of Sciences - Department of Biological and Physical Sciences|
|Date Deposited:||04 Jun 2012 05:08|
|Last Modified:||22 Aug 2014 12:21|
|Uncontrolled Keywords:||endophenotype; bipolar disorder; binocular rivalry|
|Fields of Research (FoR):||11 Medical and Health Sciences > 1109 Neurosciences > 110906 Sensory Systems
11 Medical and Health Sciences > 1103 Clinical Sciences > 110319 Psychiatry (incl. Psychotherapy)
10 Technology > 1004 Medical Biotechnology > 100402 Medical Biotechnology Diagnostics (incl. Biosensors)
|Socio-Economic Objective (SEO):||C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders|
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