Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity

Poudyal, Hemant and Brown, Lindsay (2011) Stearoyl-CoA desaturase: a vital checkpoint in the development and progression of obesity. Endocrine‚ Metabolic and Immune Disorders - Drug Targets, 11 (3). pp. 217-231. ISSN 1871-5303

Abstract

Stearoyl-CoA desaturase 1 (SCD-1) is the rate-limiting enzyme that catalyses the conversion of saturated to monounsaturated fatty acids. Increased SCD-1 expression and activity has been implicated in cancer, cardiovascular diseases, insulin resistance and obesity. Studies with humans, wild-type rodents, knock-out mice and cells in culture show that SCD-1 inhibition decreases lipogenesis and increases GLUT4-mediated glucose uptake in skeletal muscle. In this review, we will evaluate the role of SCD-1 as a homeostatic check-point between glucose and fatty acid metabolism in the development and progression of obesity. In addition to the role of SCD-1 in glucose and fatty acid metabolism, we will also discuss the expression and regulation of SCD-1, its specific interactions with inflammatory responses and PPARs, the role of SCD-1 derived MUFAs in obesity and the relevance of SCD desaturation index as a predictor of obesity and metabolic syndrome. Additionally, we will explore the prospects of SCD-1 as a potential drug target for the management of obesity and related disorders.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to published version due to publisher copyright policy. Title change, previous title was Current Drug Targets - Immune, Endocrine & Metabolic Disorders which IS in ARC list.
Depositing User: Professor Lindsay Brown
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 06 Feb 2012 05:55
Last Modified: 09 Sep 2014 23:10
Uncontrolled Keywords: stearoyl-CoA desaturase; SCD-1; metabolic syndrome; PPAR; desaturation index; MUFA; obesity; catalyses; fatty acids; insulin resistance; lipogenesis; skeletal muscle; glucose
Fields of Research (FOR2008): 06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids
Socio-Economic Objective (SEO2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified
URI: http://eprints.usq.edu.au/id/eprint/19933

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