Iyer, Abishek and Kauter, Kathleen and Brown, Lindsay (2011) Gender differences in metabolic syndrome – a key research issue. Endocrine‚ Metabolic and Immune Disorders - Drug Targets, 11 (3). pp. 182-188. ISSN 1871-5303
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Metabolic syndrome as a clustering of risk factors for diabetes and cardiovascular disease affects both men and women, but with important gender differences. Animal models have been used to understand disease progression and define therapeutic options, but most pre-clinical research on metabolic syndrome is undertaken in males. This opinion piece discusses the differences in male and female physiology that may influence both the development and the responses to pharmacological interventions of metabolic disorders, especially obesity. An appreciation of gender differences should improve the design and usefulness of biomedical experimental research to allow the development of relevant gender-based treatment options for chronic diseases including obesity, metabolic and cardiovascular diseases.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Permanent restricted access to published version due to publisher copyright policy. Title change, previous title was Current Drug Targets - Immune, Endocrine & Metabolic Disorders which IS in ARC list.|
|Uncontrolled Keywords:||female bias; metabolic syndrome; inflammation; cardiovascular disease; reproduction; rat reproductive biology; socioeconomic; uterine; breast cancers; rheumatoid arthritis; multiple sclerosis; systemic lupus; autism; schizophrenia; asthma|
|Fields of Research (FOR2008):||06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified|
11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110107 Metabolic Medicine
06 Biological Sciences > 0604 Genetics > 060403 Developmental Genetics (incl. Sex Determination)
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
|Socio-Economic Objective (SEO2008):||C Society > 92 Health > 9202 Health and Support Services > 920203 Diagnostic Methods|
|Deposited On:||06 Feb 2012 16:48|
|Last Modified:||18 Apr 2013 09:48|
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