Brown, Lindsay (2005) Cardiac extracellular matrix: a dynamic entity. American Journal of Physiology: Heart and Circulatory Physiology, 289 (3 58-3). H973-H974. ISSN 0363-6135
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Official URL: http://dx.doi.org/10.1152/ajpheart.00443.2005
Identification Number or DOI: doi: 10.1152/ajpheart.00443.2005
Understanding the regulation of the extracellular matrix of the heart is essential to understanding the chronic changes in heart function in disease states such as hypertension, heart failure, and diabetes. This understanding relies on overturning the concept that the extracellular matrix of the heart is inert. Bouzeghrane and colleagues, by showing the presence of fibrillin in rodent hearts and its upregulation in models of cardiac fibrosis, have demonstrated the dynamic complexity of the extracellular matrix. Furthermore, they have added a potential target molecule for the understanding and modification of cardiac function in both the normal and diseased heart.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Permanent restricted access to paper due to publisher copyright restrictions.|
|Uncontrolled Keywords:||heart disease; fibrillin; cardiac function|
|Fields of Research (FOR2008):||06 Biological Sciences > 0699 Other Biological Sciences > 069999 Biological Sciences not elsewhere classified|
06 Biological Sciences > 0606 Physiology > 060699 Physiology not elsewhere classified
|Socio-Economic Objective (SEO2008):||E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences|
E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences
|Deposited On:||30 Oct 2011 14:34|
|Last Modified:||13 Apr 2012 16:46|
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