Panchal, Sunil K. and Poudyal, Hemant and Iyer, Abishek and Nazer, Reeza and Alam, Md. Ashraful and Diwan, Vishal and Kauter, Kathleen and Sernia, Conrad and Campbell, Fiona and Ward, Leigh and Gobe, Glenda and Fenning, Andrew and Brown, Lindsay (2011) High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. Journal of Cardiovascular Pharmacology, 57 (5). pp. 611-624. ISSN 0160-2446
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Official URL: http://dx.doi.org/10.1097/FJC.0b013e3181feb90a
Identification Number or DOI: doi: 10.1097/FJC.0b013e3181feb90a
The prevalence of metabolic syndrome including central obesity, insulin resistance, impaired glucose tolerance, hypertension, and dyslipidemia is increasing. Development of adequate therapy for metabolic syndrome requires an animal model that mimics the human disease state. Therefore, we have characterized the metabolic, cardiovascular, hepatic, renal, and pancreatic changes in male Wistar rats (8-9 weeks old) fed on a high-carbohydrate, high-fat diet including condensed milk (39.5%), beef tallow (20%), and fructose (17.5%) together with 25% fructose in drinking water; control rats were fed a cornstarch diet. During 16 weeks on this diet, rats showed progressive increases in body weight, energy intake, abdominal fat deposition, and abdominal circumference along with impaired glucose tolerance, dyslipidemia, hyperinsulinemia, and increased plasma leptin and malondialdehyde concentrations. Cardiovascular signs included increased systolic blood pressure and endothelial dysfunction together with inflammation, fibrosis, hypertrophy, increased stiffness, and delayed repolarization in the left ventricle of the heart. The liver showed increased wet weight, fat deposition, inflammation, and fibrosis with increased plasma activity of liver enzymes. The kidneys showed inflammation and fibrosis, whereas the pancreas showed increased islet size. In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human metabolic syndrome.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Permanent restricted access to published version due to publisher copyright policy.|
|Uncontrolled Keywords:||cardiovascular disease; dyslipidemia; high-carbohydrate; high-fat diet; hypertension; metabolic syndrome; obesity|
|Fields of Research (FOR2008):||11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110102 Medical Biochemistry: Carbohydrates|
11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110104 Medical Biochemistry: Lipids
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
|Socio-Economic Objective (SEO2008):||C Society > 92 Health > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition|
|Deposited On:||30 Jun 2011 21:21|
|Last Modified:||13 Jun 2012 11:25|
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