Chan, Vincent and Fenning, Andrew and Levick, Scott P. and Loch, David and Chunduri, Prasad and Iyer, Abishek and Teo, Yi Ling and Hoey, Andrew and Wilson, Kathleen and Burstow, Darryl and Brown, Lindsay (2011) Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 57 (4). pp. 469-478. ISSN 0160-2446
Background: Cardiovascular remodeling leading to heart failure is common in the elderly. Testing effective pharmacological treatment of human heart failure requires a suitable animal model that adequately mimics the human disease state.
Methods: This study has characterized the structural, functional, and electrical characteristics of the cardiovascular system throughout the lifespan in male and female spontaneously hypertensive rats (SHRs), a genetic model of chronic hypertension–induced cardiovascular remodeling, and age- and gender-matched normotensive controls, to determine whether ageing SHRs mimic the changes seen in ageing humans.
Results: Both the ageing mle and female SHRs developed progressive hypertension, ventricular hypertrophy, left ventricular fibrosis, action potential prolongation without impaired glucose tolerance. Male SHRs from 15 months of age exhibited left ventricular wall thinning and chamber dilation, together with systolic and diastolic dysfunction and increased cardiac stiffness and increased erythrocyte superoxide production, which were not present in the female SHRs.
Conclusion: Ageing male SHRs in contrast to the female SHRs, better mimic the chronic heart failure in humans produced by chronic hypertension. Ageing male SHRs could then be used to investigate proposed therapeutic interventions for chronic congestive heart failure in humans.
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|Item Type:||Article (Commonwealth Reporting Category C)|
|Publisher:||Lippincott Williams & Wilkins|
|Item Status:||Live Archive|
|Additional Information (displayed to public):||Permanent restricted access to published version due to publisher copyright policy.|
|Depositing User:||Professor Lindsay Brown|
|Faculty / Department / School:||Historic - Faculty of Sciences - Department of Biological and Physical Sciences|
|Date Deposited:||29 Jun 2011 11:28|
|Last Modified:||24 Aug 2014 23:54|
|Uncontrolled Keywords:||ageing; gender; heart failure; hypertension; remodeling; spontaneously hypertensive rats|
|Fields of Research (FoR):||10 Technology > 1004 Medical Biotechnology > 100402 Medical Biotechnology Diagnostics (incl. Biosensors)
11 Medical and Health Sciences > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
|Socio-Economic Objective (SEO):||E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences|
|Identification Number or DOI:||doi: 10.1097/FJC.0b013e3182102c3b|
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