Iyer, Abishek and Brown, Lindsay (2010) Lipid mediators and inflammation in glucose intolerance and insulin resistance. Drug Discovery Today: Disease Mechanisms, 7 (3-4). e191-e197.
Clinical and epidemiological studies suggest that patients who are overweight or obese are at greater risk to develop glucose intolerance and insulin resistance leading to type II diabetes and cardiovascular disease. Despite many hypotheses, it has been difficult to pin-point the precise causes of insulin resistance or impaired glucose tolerance. This commentary aims to stimulate debate by providing some mechanistic insights into a unifying hypothesis by which disturbed lipid metabolism, increased circulating lipid-derived mediators and excess accumulation of toxic lipid metabolites in adipose, muscle, liver and pancreatic beta cells contribute to inflammation, insulin resistance and beta cell dysfunction in type II diabetes. This understanding will direct future drug discovery research to identify and develop novel compounds that can regulate both metabolic and immune/inflammatory systems to provide a dual strategy to combat metabolic disease, especially insulin resistance and type II diabetes.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Author version not held.|
|Uncontrolled Keywords:||metabolic disease; lipids; lipid metabolism; adipose tissue; adipose tissue cell; asthma; body mass; cardiovascular disease; cell stress|
|Depositing User:||Ms Debbie White|
|Date Deposited:||22 Mar 2011 12:59|
|Last Modified:||03 Jul 2013 00:34|
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