Rickman, Celestine and Iyer, Abishek and Chan, Vincent and Brown, Lindsay (2010) Green tea attenuates cardiovascular remodeling and metabolic symptoms in high carbohydrate-fed rats. Current Pharmaceutical Biotechnology, 11 (8). pp. 881-886. ISSN 1389-2010
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Official URL: http://www.bentham.org/cpb/contabs/cpb11-8.htm#11
Excess carbohydrate in the diet may initiate a chronic state of oxidative stress exacerbating the clinical and biochemical symptoms of diet-induced type 2 diabetes, especially glucose intolerance, lipid abnormalities and cardiovascular complications. This study has tested whether green tea, rich in antioxidants, improves both cardiovascular symptoms and glucose intolerance and also reduces oxidative stress in rats fed a high carbohydrate diet. Male 8 week old Wistar rats were fed a diet including fructose and condensed milk (each 40%) for 16 weeks (112 days); control rats were fed corn starch. Green tea-containing food was started from day 1 for the prevention protocol and from day 56 for the reversal protocol. High carbohydrate diet-fed rats showed glucose intolerance, hypertension, mild left ventricular hypertrophy, approximate doubling of cardiac interstitial and perivascular collagen deposition, increased passive diastolic stiffness and increased plasma malondialdehyde concentrations. Administration of green tea to high carbohydrate diet-fed rats prevented and reversed glucose intolerance and the increased systolic blood pressure, left ventricular wet weight, interstitial collagen and passive diastolic stiffness. Plasma malondialdehyde concentrations were also normalized. In summary, treatment with green tea both prevented and reversed the cardiovascular remodeling and metabolic changes seen in high carbohydrate-fed rats suggesting a chronic state of oxidative stress plays a key role in the symptom initiation and progression. Further, green tea may be a useful complementary therapy in diet induced type 2 diabetes.
|Item Type:||Article (Commonwealth Reporting Category C)|
|Additional Information:||Permanent restricted access to published version due to publisher copyright restrictions.|
|Uncontrolled Keywords:||green tea; remodeling; obesity; diabetes; rats; oxidative stress; carbohydrate; antioxidants; cardiovascular; intolerance; hypertension; diastolic stiffness; plasma malondialdehyde; systolic blood pressure; nephropathy; retinopathy; insulin; polyphenolic compounds; epigallocatechins; cardiovascular diseases; insulin resistance|
|Fields of Research (FOR2008):||11 Medical and Health Sciences > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified|
11 Medical and Health Sciences > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology
11 Medical and Health Sciences > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl. Cardiovascular Diseases)
|Socio-Economic Objective (SEO2008):||E Expanding Knowledge > 97 Expanding Knowledge > 970111 Expanding Knowledge in the Medical and Health Sciences|
|Deposited On:||10 Mar 2011 18:39|
|Last Modified:||22 Mar 2012 13:16|
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