Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp.

Michael, Adam P. and Grace, Emily J. and Kotiw, Michael and Barrow, Russell A. (2003) Isochromophilone IX, a novel GABA-containing metabolite isolated from a cultured fungus, Penicillium sp. Australian Journal of Chemistry, 56 (1). pp. 13-15. ISSN 0004-9425

Abstract

Isochromophilone IX, a novel antibiotic active component was isolated from a penicillium species and investigated. Isochromophilone IX displays a specific rotation with the same sign as isochromophilone VI. It was found that isochromophilone represents the first occurrence of an γ-amino butyric acid (GABA) containing metabolite among only four naturally occuring members of this structure class.


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Item Type: Article (Commonwealth Reporting Category C)
Refereed: Yes
Item Status: Live Archive
Additional Information: Permanent restricted access to paper due to publisher copyright restrictions. (CSIRO)
Depositing User: Bulkimport bulkimport
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 30 Nov 2007 11:47
Last Modified: 03 Jul 2013 00:20
Uncontrolled Keywords: amino acids; fungi; high performance liquid chromatography; isomers; mass spectrometry; metabolites
Fields of Research (FOR2008): 06 Biological Sciences > 0605 Microbiology > 060501 Bacteriology
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11 Medical and Health Sciences > 1101 Medical Biochemistry and Metabolomics > 110101 Medical Biochemistry: Amino Acids and Metabolites
10 Technology > 1004 Medical Biotechnology > 100403 Medical Molecular Engineering of Nucleic Acids and Proteins
Socio-Economic Objective (SEO2008): E Expanding Knowledge > 97 Expanding Knowledge > 970106 Expanding Knowledge in the Biological Sciences
Identification Number or DOI: doi: 10.1071/CH02021
URI: http://eprints.usq.edu.au/id/eprint/14391

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