Effect of canine hyperimmune plasma on TNFa and inflammatory cell levels in a lipopolysaccharide-mediated rat air pouch model of inflammation

Strunin, Dmitry and Essien, Bryan and Kotiw, Michael and Butler, Harry (2009) Effect of canine hyperimmune plasma on TNFa and inflammatory cell levels in a lipopolysaccharide-mediated rat air pouch model of inflammation. In: Sepsis 2009: Critical Care Conference, 11-14 Nov 2009, Amsterdam, Netherlands.

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Abstract

The purpose of this study was to test the effect of canine hyperimmune frozen plasma (HFP), which is known to contain elevated levels of soluble TNFα receptor 1 (sTNFR1), on TNFα and inflammatory cell levels in a LPS-mediated rat air pouch model of inflammation. There appears to be a correlation between elevated levels of sTNFR1 and depression of TNFα and neutrophil levels in the pouch fluid of HFP dosed rats (r = -0.73, P < 0.0001). The data suggest that canine HFP, which has been demonstrated to contain elevated levels of sTNFR1 compared with FFP, has a direct effect on depressing TNFα levels and neutrophil sequestration in the rat air pouch model of inflammation. These data suggest that HFP may be worthy of further investigation to determine whether such preparations have a therapeutic potential for treatment of acute inflammatory diseases in which TNFα is implicated.


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Item Type: Conference or Workshop Item (Commonwealth Reporting Category E) (Poster)
Refereed: Yes
Item Status: Live Archive
Additional Information: This is a post paper. Published in Critical Care Volume 13 Suppl 4, 2009, Paper P8.
Depositing User: Bulkimport bulkimport
Faculty / Department / School: Historic - Faculty of Sciences - Department of Biological and Physical Sciences
Date Deposited: 12 Feb 2010 16:25
Last Modified: 03 Jul 2013 00:18
Fields of Research (FOR2008): 11 Medical and Health Sciences > 1107 Immunology > 110702 Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies)
06 Biological Sciences > 0605 Microbiology > 060501 Bacteriology
06 Biological Sciences > 0605 Microbiology > 060502 Infectious Agents
Socio-Economic Objective (SEO2008): C Society > 92 Health > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy
Identification Number or DOI: doi: 10.1186/cc8064
URI: http://eprints.usq.edu.au/id/eprint/13278

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